Endocrine Abstracts

Background: Stiff Person Syndrome (SPS) is an extremely rare neurological disorder, with an expected prevalence of less than 1 per million. The first described case of SPS in the literature was reported in 1959 by Moersch and Woltman. SPS is featured by progressive muscle stiffness, rigidity, and spasm involving the axial muscles, which may result in severely impaired ambulation. SPS seems to have an autoimmune basis although its exact pathogenic mechanism is still cloudy. Mos...